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Study provides more insight into the initiation and progress


时间:2020-05-08 10:15 发布人:孕宝国际   来源:孕宝国际试管婴儿中心

  Volume 11, Issue 18 of @Oncotarget Clinical implications of chromatin accessibility assessed by ATAC-seq profiling in human cancers especially in a large patient cohort is largely unknown.

  In this study, the authors analyzed ATAC-seq data in 404 cancer patients from the Cancer Genome Atlas, representing the largest cancer patient cohort with ATAC-seq data, and correlated chromatin accessibility with patient demographics, tumor histology, molecular subtypes, and survival.

  Chromatin accessibility, especially on the X chromosome, is strongly dependent on patient sex, but not much on patient age or tumor stage.

  Dr. Yuexin Liu from The Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA said,

  Cancer is a heterogeneous disease with a diversity of cell types which thus play a deterministic role on patient outcome or therapeutic responses."

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